Increasing data have shown the significance of various miRNAs in
malignancy. In this regard, parallel to its biological role in normal
tissues, miRNA-128 (miR-128) has been found to play an essential
immunomodulatory function in the process of cancer initiation and
development. The occurrence of the aberrant expression of miR-128 in
tumors and the unique properties of miRNAs raise the prospect of their
use as biomarkers and the next generation of molecular anticancer
therapies. The function of miR-128 in malignancies such as breast,
prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian
and bladder cancers and hepatocellular carcinoma is discussed in this
review. Finally, the effect of exosomal miR-128 on cancer resistance to
therapeutics and cancer immunotherapy in certain malignancies is
highlighted.