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Towards Screening and Repurposing of Approved Drugs for the Treatment of COVID-19 Using Molecular Docking

Recent Patents and FDA-Approved Drugs Based on Antiviral Peptides and Other Peptide-Related Antivirals

Gefitinib-loaded polydopamine-coated hollow mesoporous silica nanoparticle for gastric cancer application

Extension of human GCSF serum half-life by the fusion of albumin binding domain

A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles

Determination of antifungal activity and action mechanism of the modified Aurein 1.2 peptide derivatives

Bacterial production and biophysical characterization of a hard-to-fold scFv against myeloid leukemia cell surface marker, IL-1RAP

In Silico Design and In Vitro Evaluation of Some Novel AMPs Derived From Human LL-37 as Potential Antimicrobial Agents for Keratitis

Expression of cathelicidin, ERK, MyD88, and TLR-9 in the blood of women in the pre-pregnancy, pregnancy, and their infant cord blood

Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraYCB-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculation

Antibiotic resistance pattern and frequency of SHV, CTX, TEM, and OXA resistance gene among salmonella serotypes

Design and development of a self-assembling protein nanoparticle displaying PfHAP2 antigenic determinants recognized by natural acquired antibodies

Evaluation of Antibacterial, Antifungal, and Cytotoxicity Effects of CecropinA-Magenin2 (CE-MA) Peptide and Its Truncated Derivatives and Study of Their Action Mechanism

Biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and penicillin G by the natural microflora

COVID-19: A systematic review and update on prevention, diagnosis, and treatment

Enfuvirtide, an HIV-1 fusion inhibitor peptide, can act as a potent SARS-CoV-2 fusion inhibitor: an in silico drug repurposing study

Chitosan hydrogel/silk fibroin/Mg(OH)2 nanobiocomposite as a novel scaffold with antimicrobial activity and improved mechanical properties

Pectin-cellulose hydrogel, silk fibroin and magnesium hydroxide nanoparticles hybrid nanocomposites for biomedical applications

Strategies in design of antibodies for cancer treatment

Pasteurella multocida PlpE Protein Polytope as a Potential Subunit Vaccine Candidate

Efficient pyran derivatives synthesis in DES medium and their antimicrobial evaluation as inhibitors of mycobacterium bovis (BCG)

Targeted delivery of paclitaxel by NL2 peptide-functionalized on core-shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Functionalized magnetic nanoparticles for the separation and purification of proteins and peptides

Synthesis, antimycobacterial and anticancer activity of novel indole-based thiosemicarbazones

Hybrid Bionanocomposite Containing Magnesium Hydroxide Nanoparticles Embedded in a Carboxymethyl Cellulose Hydrogel plus Silk Fibroin as a Scaffold for Wound Dressing Applications

Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains

Surface display of pancreatic lipase inhibitor peptides by engineered Saccharomyces boulardii: Potential as an anti-obesity probiotic

Synthesis of the scFv fragment of anti-Frizzled-7 antibody and evaluation of its effects on triple-negative breast cancer in vitro study

In silico designing a novel TLR4-mediating multiepitope vaccine against monkeypox via advanced immunoinformatics and bioinformatics approaches

Molecular imprinting of miR-559 on a peptide-immobilized poly L-DOPA/silica core-shell and in vitro investigating its effects on HER2-positive breast cancer cells

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The Medical Biotechnology Group > Drug Design & Bioinformatics Group (Prof. Soroush Sardari)

The main focus of the Drug Design & Bioinformatics Group is on antimicrobial and anti-cancer drugs. Moreover, natural compounds with the desired activity are also studied. In the design of active ingredients (Active ingredients), cheminformatics and bioinformatics methods are being employed. In these methods, various types of software are used and the design of drugs, changes in in silico proteins in relation to infectious diseases, cancer, etc. The simulation activity of nanostructures is processing in the field of Nanodrug loading and delivery. Ultraviolet spectroscopy (UV) and circular dichroism (CD) are used in this regard as computer instruments. New manufacturing and productivity is done from databases using high-volume pattern recognition techniques.

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