30/05/1402
Strategies in design of antibodies for cancer treatment
Structural bioinformatics and computational methodologies facilitate
antibodies design. The rational design is used to achieve a new function
or adopt a new structure. Computer algorithms can systematically search
amino acid sequences and select the best one. One of the important
points of protein therapeutics is utilizing as drug. The present study
reviewed recent studies about antibody design, antibody structure
modeling, antibody prediction, and stability, pharmacokinetics and
recent algorithms used in antibody design. By advanced technology with
computational technologies development of therapeutics antibodies is
possible. In early stages, several methods of predicting protein
structure and de novo protein design were presented.