15/05/1402
Pectin-cellulose hydrogel, silk fibroin and magnesium hydroxide nanoparticles hybrid nanocomposites for biomedical applications
Natural polymers are at the center of materials development
for biomedical and biotechnological applications based on their
biocompatibility, low-toxicity and biodegradability. In this study, a novel nanobiocomposite based on cross-linked pectin-cellulose hydrogel, silk fibroin, and Mg(OH)2
nanoparticles was designed and synthesized. After extensive
physical-chemical characterization, the biological response of
pectin-cellulose/silk fibroin/Mg(OH) 2 nanobiocomposite scaffolds was evaluated by cell viability,
red blood cells hemolytic and anti-biofilm assays. After 3 days and
7 days, the cell viability of this nanobiocomposite scaffold was 65.5%
and 60.5% respectively. The hemolytic effect was below 20%. Furthermore,
the presence of silk fibroin and Mg(OH)2 nanoparticles allowed to enhance the anti-biofilm activity, inhibiting the P. aeruginosa biofilm formation.
|