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Ichthyosis follicularis syndromes in patients with mutations in GJB2

Lentiviral vector containing beta-globin gene for beta thalassemia gene therapy

Ichthyosis, psoriasiform dermatitis, and recurrent fungal infections in patients with biallelic mutations in PERP

Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses

Molecular investigation of association between common IL-6 polymorphism with cytomegalovirus (CMV) infection and recurrent miscarriage in Iranian women

Low expression of isocitrate dehydrogenase 1 (IDH1) R132H is associated with advanced pathological features in laryngeal squamous cell carcinoma

Detection of Helicobacter pylori genes (CagA and VacA) in municipal drinking water

Repurposing antiviral drugs against HTLV-1 protease by molecular docking and molecular dynamics simulation

Evaluation of the dual effects of antiviral drugs on SARS-CoV-2 receptors and the ACE2 receptor using structure-based virtual screening and molecular dynamics simulation

Characterization of SARS-CoV-2 omicron variants from Iran and evaluation of the effect of mutations on the spike, nucleocapsid, ORF8, and ORF9b proteins function

Anti-angiogenic peptides application in cancer therapy; a review

LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan

Oncolytic herpes simplex virus type-1 expressing IL-12 efficiently replicates and kills human colorectal cancer cells

Comprehensive Mutation Analysis and Report of 12 Novel Mutations in a Cohort of Patients with Spinal Muscular Atrophy in Iran

Association of SLC22A1,SLCO1B3 Drug Transporter Polymorphisms and Smoking with Disease Risk and Cytogenetic Response to Imatinib in Patients with Chronic Myeloid Leukemia

Biallelic variants in MESD, which encodes a WNT-signaling-related protein, in four new families with recessively inherited osteogenesis imperfecta

miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway

Lessons for preparedness and reasons for concern from the early COVID-19 epidemic in Iran

Evaluation of the immune response to a multi-epitope vaccine candidate in comparison with HlaH35L, MntC, and SACOL0723 proteins against MRSA infection

Targeted integration into pseudo attP sites of CHO cells using CRISPR/Cas9

Distal Renal Tubular Acidosis in an Iranian Patient with Hereditary Spherocytosis

Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder

PastoCovac and PastoCovac Plus as protein subunit COVID-19 vaccines led to great humoral immune responses in BBIP-CorV immunized individuals

Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients susceptibility to COVID-19 to the possible caution of future global diabetes tsunami

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii

Targeting long non-coding RNA MALAT1 reverses cancerous phenotypes of breast cancer cells through microRNA-561-3p/TOP2A axis

Evaluation of TUBB8 gene alterations in infertile women with oocyte maturation and cleavage arrest referred to Royan Institute

Molecular Investigation of the Association Among Common Interleukin-6 Polymorphism and Human Papillomavirus Genotypes with Cervical Cancer Among Iranian Women

A novel de novo canonical splice site mutation in the PTCH1 gene in a male patient with mild psychomotor retardation and autistic traits: a case report

Identifying and predicting the pathogenic effects of a novel variant inducing severe early onset MMA: a bioinformatics approach

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The Molecular Medicine Group > Molecular Genetic of disease (Prof. Sirous Zienali & Prof. Reza Mahdian)

The activity of this group is done inside the Molecular Medicine Department of the Pasteur Institute of Iran and with the priority of molecular studies in the field of human and medical genetics. Identification of the mutations that cause common genetic diseases in Iran, such as thalassemia, hemophilia, and Duchenne muscular dystrophy. The special clinic of genetics and PND in this section is the National Reference Center for Prenatal Diagnosis of Thalassemia & Hemoglobinopathies that provides counseling and laboratory trouble-shooting, as well as the transfer of prenatal diagnostic technology to newly established centers in addition to performing prenatal diagnostic services. Common national mutations have also been achieved in the field of hemophilia B and the diagnosis of Duchenne vectors has been carried out by the Real-Time PCR method in this unit.

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