30/05/1402
T lymphocytes and preeclampsia: The potential role of T-cell subsets and related MicroRNAs in the pathogenesis of preeclampsia
Innate and adaptive immune systems have a crucial role in initiating and
progressing some pregnancy disorders such as preeclampsia (PE), which
is one of the pregnancy specific disorders that could result in neonatal
and maternal morbidity and mortality. The dysregulation of the spiral
artery and inadequate trophoblast invasion lead to PE symptoms through
producing various inflammatory cytokines and anti-angiogenic factors
from the placenta. T lymphocytes play a special role in the epithelium
and stroma of the human endometrium. CD4+ T helper (Th) cells, Th1/Th2,
and Th17/T regulatory (Treg) balance mainly contribute to the
establishment of a pregnancy favorable environment. This review examined
the dysregulation of some cytokines produced from T cells, the
dysregulation of the transcription factors of Th cells, the expression
of chemokine receptors on T cells, as well as the effects of some
factors including vitamin D on the activity of T cells, and finally, the
dysregulation of various miRNAs related to T cells, which could cause
PE.