Silk fibroin/gelatin/nanohydroxyapatite (SF/GE/nHAp) composite scaffolds were prepared from the

mixture of silk fibroin, gelatin and nHAp in different inorganic/organic weight ratios by employing the

freeze-drying approach. The prepared nHAp and composite scaffolds were investigated using BET, FT-IR,

SEM, and XRD studies. The composite scaffolds had 45e60% porosities with well-defined interlinked

porous networks. In addition, the investigation of the cell proliferation, adhesion and viability using MTT,

DMEM solution, and mouse preosteoblast cell confirmed the cytocompatible nature of the composite

scaffolds with improved cell proliferation and attachment. All these results essentially showed that this

composite could be a potential candidate for bone tissue engineering application.